Samstag, 13. April 2013

The Hypothalamus and Aging

The hypothalamus regulates lots of things including satiety (esp. lateral and ventromedial hypothalamus), temperature and many hormones relevant to aging.

Seriously, why has no one performed these studies? At least not to my knowledge:
This review compares outcomes of lesions in the VMN, DMN [ventro- and dorsomedial nucleus], and lateral hypothalamic area (LHA) for relevance to aging. To establish a relationship between these anatomic areas of the hypothalamus and aging, it is concluded that the VMN, DMN, and LHA lesions should be examined for impact on longevity and compared with data obtained from simultaneously studied intact ad-lib-fed and 40% calorie-restricted animals. Lesioned animals also should be rigorously studied for neurotransmitters (e.g., neuropeptide Y, beta-endorphin, serotonin, corticotropin-releasing factor, and galanin), and for behavioral changes consistent with aging, for accumulation of specific tissue lipofuscin and amyloid that are associated with normal aging and for other age-dependent findings, such as incidence of tumors and cataract.

Physiol Behav. 1996 Mar;59(3):523-36.
Aging and the hypothalamus: research perspectives.
Bernardis LL, Davis PJ.

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